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Sex Differences and Organizational Effects of Androgen in Spinal Cord Motor Nuclei William Grisham, University of California - Los Angeles Heidi B. Jones Sun Hee Park
From the The Journal of Undergraduate Neuroscience Education (JUNE), Fall 2003, 2(1): A28-A35.
ABSTRACT: This article describes a laboratory module taught at
UCLA and offers digitized microscope images that will
allow instructors to recreate this module at their home
institutions with only a computer required. This module
allows for 1) an exploration of the effects of hormones on
neural development, 2) the demonstration of sex
differences in the nervous system, 3) the production of
robust and statistically significant data by novice
undergraduates, 4) the discussion of sophisticated
statistical analyses (ANOVAs with significant main effects
and an interaction), and 5) the understanding of at least
some of the neuroanatomy of the spinal cord. Specifically,
this module both replicates and extends a previously
published experiment on sexually dimorphic neurons in the
spinal cord of rats (Grisham et al., 1992), which examined
the effect of antiandrogen exposure (Flutamide) in utero on sexually dimorphic spinal motoneurons in male and female
rats.
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