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Download the Paper (2.6 MB, PDF file) - April 1, 2006 Tell a colleague about it. Printing Tips: Select 'print as image' in the Acrobat print dialog if you have trouble printing.

ABSTRACT:
We discuss the value of volume measures for linkage disequilibrium, showing how they are robust to small sample variation and easily generalized to multi-allelic markers. In particular we introduce Dvol, a volume analogue to D' and show that it performs substantially better when the sample size is small to moderate. Mvol is proposed as a generalization of this measure to multi-allelic markers. Finally a measure based on homozygosity Hvol is suggested as a generalization of R^2. To evaluate these measures, we introduce a sequential importance sampling algorithm. We illustrate their performance on simulated and real data.

SUGGESTED CITATION:
Yuguo Chen, Chia-Ho Lin, and Chiara Sabatti, "Volume Measures for Linkage Disequilibrium" (April 1, 2006). Department of Statistics, UCLA. Department of Statistics Papers. Paper 2006040101.
http://repositories.cdlib.org/uclastat/papers/2006040101